The disruption of the IS/OS junction, ELM, and IZ have a deleterious effect on visual function. The morphologic analysis of the integrity or disruption of these retinal layers as clinical markers for predicting visual outcome has been the subject of previous investigations. Four hyperreflective lines are identified in the outer retina by SD-OCT, the external limiting membrane (ELM), the inner and outer photoreceptor segments junction (IS/OS), also known as the ellipsoid portion of inner segments (EPIS/Ellipsoid zone), the cone outer segment tips (COST) or interdigitating zone (IZ), and the retinal pigment epithelium (RPE). One of many advantages of SD-OCT is that it provides rapid acquisition of noninvasive high-resolution images of all retinal layers. Macular spectral-domain ocular coherence tomography (SD-OCT) provides qualitative and quantitative data to confirm, classify the morphology, measure the thickness, and monitor the treatment response. However, there is a need for more objective ways to correlate the degree of visual loss with the macular microstructural changes to make the right therapeutic decisions and better judge these patients’ visual prognosis. On the other hand, the increase in retinal thickness affects visual acuity and is considered an important contributor to UME´s visual loss. According to the vast majority of studies, CME is the most frequent type causing both legal blindness (29%) and visual impairment (41%). Although epiretinal membrane (ERM) and vitreomacular traction (VMT) are not caused by fluid accumulation, their contribution to the pathogenesis of macular thickening has granted their consideration as part of the UME clinical spectrum by some authors. The anatomical subtypes of macular edema include diffuse macular edema (DME), cystoid macular edema (CME), serous retinal detachment (SRD) or subretinal fluid (SRF), and vitreoretinal interface abnormalities. Uveitic macular edema (UME) is more commonly found in chronic disorders where vitreous inflammation occurs, particularly in intermediate uveitis (25–70%), panuveitis (35%), and posterior uveitis (20%). Uveitis encompasses a diverse group of ocular inflammatory disorders, leading to potential sight-threatening complications such as cataracts, glaucoma, and macular edema, the latter being the most common cause of visual impairment in up to 41% of patients. CONBIOETICA 19 CEI 011-), project registration No. P000338-CAVICaREMU-CI-CR002, and the Ethics Committee (License No. COFEPRIS 20 CI 19 039 002), project registration No. Trial registration The study was registered on April 13, 2020, at the Instituto Tecnologico y de Estudios Superiores de Monterrey Research Committee (License No. Evaluating these layers’ integrity by optical coherence tomography helps predict the visual outcome and make the right therapeutic decisions. Significantly increased CFT has a higher probability for EPIS and IZ disruption, which significantly increases the risk for irreversible visual loss in eyes with UME. Likewise, an increased probability of severe visual loss correlated negatively with both, IZ (37.93%, P ≤ 0.001, OR 10.02) and EPIS (38.98%, P ≤ 0.001, OR 13.1) disruption. Of all morphological patterns of macular edema, only CME showed a statistically significant relationship with severe visual impairment (44.92%, p = 0.0035, OR 4.29 ). Cystoid macular edema (CME) increased the risk of severe (P ≤ 0.0162) and moderate visual loss (P ≤ 0.0032). We included 145 SD-OCT macular scans from 45 patients at different stages of UME. Receiver operator curve (ROC) estimation and logistic regression (probit) assessed if the sample´s variance could be associated with IZ or EPIS integrity. We arranged the data by EPIS or IZ integrity and contrasted it with student t-test (quantitative variables) and Fisher exact test or χ² distribution (categorical variables) to evaluate visual impairment and retinal measures. Spectral-domain optical coherence tomography (SD-OCT) macular morphological pattern, CFT, and integrity of the outer retinal layers were analyzed. Prospective, observational, and cross-sectional study of eyes with UME. To analyze the relationship between the central foveal thickness (CFT) and the integrity of the ellipsoid portion of inner segments (EPIS) and interdigitating zone (IZ) retinal layers in the visual outcome of uveitic macular edema (UME).
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